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Puerarin

5-HT2c inhibitor
 
ALX-350-249-M005 5 mg 103.00 USD
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Biologically active isoflavone. Affects serotonin levels and platelet aggregation in blood cells. 5-HT2c antagonist. Antibacterial. Displays cardioprotective effects. Induces apoptosis.

Product Specification

Alternative Name:8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, NPI-031G
 
Formula:C21H20O9
 
MW:416.4
 
Source:Isolated from Kudzu root.
 
CAS:3681-99-0
 
RTECS:UO5216000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
350-249
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350-249

Product Literature References

Puerarin inhibits proliferation and induces apoptosis in human glioblastoma cell lines: J. Yang, et al.; Int. J. Clin. Exp. Med. 8, 10132 (2015), Application(s): Effect of puerarin on human glioblastoma cells, Abstract; Full Text
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin: 574, 179 (2007) : Q. Gao, et al.; Eur. J. Pharmacol. 574, 179 (2007), Abstract;
Induction of apoptosis by puerarin in colon cancer HT-29 cells: Z. Yu & W. Li; Cancer Lett. 238, 53 (2006), Abstract;
Contrasting effects of puerarin and daidzin on glucose homeostasis in mice: E. Meezan, et al.; J. Agric. Food Chem. 53, 8760 (2005), Abstract;
Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells: C.P. Mao & Z.L. Gu; Acta Pharmacol. Sin. 26, 982 (2005), Abstract;
NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists: D.H. Overstreet, et al.; Pharmacol. Biochem. Behav. 75, 619 (2003), Abstract;
Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS 95, 2198 (1998), Abstract;
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull. 21, 628 (1998), Abstract;

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