Plant polyphenol. Specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60c-src. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.
Product Details
| Alternative Name: | 2',3,4,4'-Tetrahydroxychalcone |
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| Formula: | C15H12O5 |
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| MW: | 272.3 |
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| CAS: | 487-52-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Identity determined by 1H-NMR, 13C-NMR and MS. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (>50mg/ml) or methanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Keep cool and dry under inert gas. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue: M.K. Pandey, et al.; J. Biol. Chem.
282, 17340 (2007),
Abstract;
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase: Y. Wang, et al.; Life Sci.
77, 39 (2005),
Abstract;
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature
425, 191 (2003),
Abstract;
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells: N.Y. Kim, et al.; Pharmacol. Toxicol.
88, 261 (2001),
Abstract;
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells: K. Iwashita, et al.; Biosci. Biotechnol. Biochem.
64, 1813 (2000),
Abstract;
Antioxidant properties of butein isolated from Dalbergia odorifera: Z.J. Cheng, et al.; Biochim. Biophys. Acta
1392, 291 (1998),
Abstract;
Butein, a specific protein tyrosine kinase inhibitor: E.-B. Yang, et al.; BBRC
245, 435 (1998),
Abstract;
Inhibition of glutathione reductase by plant polyphenols: K. Zhang, et al.; Biochem. Pharmacol.
54, 1047 (1997),
Abstract;
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3): K. Hayashi, et al.; Eur. J. Pharmacol.
316, 297 (1996),
Abstract;
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor: S.M. Yu, et al.; Eur. J. Pharmacol.
280, 69 (1995),
Abstract;
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation: C.C. Yit & N.P. Das; Cancer Lett.
82, 65 (1994),
Abstract;
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase: K. Zhang & N.P. Das; Biochem. Pharmacol.
47, 2063 (1994),
Abstract;
Protective effects of hydroxychalcones on free radical-induced cell damage: S. Sogawa, et al.; Biol. Pharm. Bull.
17, 251 (1994),
Abstract;
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects: E. Aizu, et al.; Carcinogenesis
7, 1809 (1986),
Abstract;
