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Gramicidin A

Ionophore antibiotic
 
ALX-350-233-M001 1 mg 44.00 USD
 
ALX-350-233-M005 5 mg 89.00 USD
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Naturally occurring ion channel forming pentadecapeptide. Causes K+/H+-exchange in mitochondria in a non-voltage dependent manner.

Product Specification

Sequence:HCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH2CH2OH
 
Formula:C99H140N20O17
 
MW:1882.3
 
Source:Isolated from Bacillus brevis.
 
CAS:11029-61-01
 
MI:14: 4532
 
RTECS:MD8230000
 
Purity:≥90% (HPLC)
 
Purity Detail:Contaminants: ≤5% Gramicidin C (HPLC).
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO, lower alcohols or acetic acid.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 

Product Literature References

Effects of gramicidin-A on the adsorption of phospholipids to the air-water interface: S.C. Biswas, et al.; Biochim. Biophys. Acta 1717, 41 (2005), Abstract;
Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A: B.S. Prabhananda & M.H. Kombrabail; Biophys. J. 71, 3091 (1996), Abstract;
Palmitoylation-induced conformational changes of specific side chains in the gramicidin transmembrane channel: R.E. Koeppe, 2nd, et al.; Biochemistry 34, 9299 (1995), Abstract;
The permeation properties of small organic cations in gramicidin A channels: S.A. Seoh & D. Busath; Biophys. J. 64, 1017 (1993), Abstract;
Purification of gramicidin A: C.J. Stankovic, et al.; Anal. Biochem. 184, 100 (1990), Abstract;

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