R,S-Sulforaphane is a synthetic version of the naturally occurring compound, R-sulforaphane, from Broccoli. It is a racemic mixture of both the R and S isomers.
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.
Product Details
| Alternative Name: | D,L-Sulforaphane, 1-Isothiocyanato-4-methylsulfinyl-butane |
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| Formula: | C6H11NOS2 |
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| MW: | 177.3 |
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| Source: | Synthetic. |
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| CAS: | 4478-93-7 (unspecified stereo) |
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| MI: | 14: 8962 |
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| Purity: | ≥98% (UHPLC) |
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| Identity: | Identity determined by 1H-NMR and MS. |
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| Appearance: | Slightly yellowish liquid. |
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| Solubility: | Soluble in methanol or DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Simultaneous quantification of sulforaphene and sulforaphane by reverse phase HPLC and their content in Raphanus sativus L. var. caudatus Alef extracts: S. Sangthong, et al.; Food. Chem.
201, 139 (2016),
Application(s): Standard,
Abstract;
4-Methylthiobutyl isothiocyanate (Erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells: C. Gründemann, et al.; Phytomedicine
22, 369 (2015),
Application(s): Gas Chromatography - Mass Spectrometry ,
Abstract;
Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells: Y. Wang, et al.; Nutr. Res.
35, 610 (2015),
Abstract;
Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol.
64, 503 (2012),
Abstract;
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut
58, 949 (2009),
Abstract;
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther.
316, 1070 (2006),
Abstract;
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res.
64, 5767 (2004),
Abstract;
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Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS
91, 3147 (1994),
Abstract;
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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS
89, 2399 (1992),
Abstract;
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