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Kahweol

GST activator
 
ALX-350-223-M010 10 mg 116.00 USD
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Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.

Product Specification

Formula:C20H26O3
 
MW:314.2
 
Source:Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
 
CAS:6894-43-5
 
Purity:≥97% (UPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in ethyl acetate, acetone or DMSO; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-223
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350-223

Product Literature References

The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells: H.G. Kim, et al.; Toxicol. Appl. Pharmacol. 217, 332 (2006), Abstract;
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002), Abstract;
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998), Abstract;
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat: W.W. Huber, et al.; Mutat. Res. 376, 115 (1997), Abstract;
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol: B. Schilter, et al.; Carcinogenesis 17, 2377 (1996), Abstract;
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice: L.K. Lam, et al.; J. Med. Chem. 30, 1399 (1987), Abstract;
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res. 42, 1193 (1982), Abstract;
The chemistry of the coffee-bean: I. Concerning the unsaponifiable matter of the coffee-bean oil. Preparation and properties of kahweol: R.O. Bengis & R.J. Anderson; J. Biol. Chem. 97, 99 (1932), Full Text

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GST activator
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