Inducer of glutathione S-transferases. Has chemoprotective activity, reducing the genotoxicity of several carcinogens.
Product Details
| Formula: | C20H28O3 |
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| MW: | 316.4 |
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| Source: | Isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans. |
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| CAS: | 469-83-0 |
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| MI: | 14: 1634 |
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| Purity: | ≥98% (UHPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO, 100% ethanol or ethyl acetate. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol.
40, 1155 (2002),
Abstract;
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis
19, 1369 (1998),
Abstract;
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res.
42, 1193 (1982),
Abstract;
Zur Chemie des Kaffees, IV. Mitteil.: Zur Konstitutionsaufklärung des Cafesterols: K.H. Slotta & K. Neisser; Ber. dtsch. chem. Ges. 71, 1991 (1938),
The chemistry of the coffee-bean: I. Concerning the unsaponifiable matter of the coffee-bean oil. Preparation and properties of kahweol: R.O. Bengis & R.J. Anderson; J. Biol. Chem.
97, 99 (1932),
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