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Artemisinin

iNOS inhibitor
 
ALX-350-219-M100 100 mg 41.00 USD
 
ALX-350-219-G001 1 g 249.00 USD
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Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).

Product Specification

Alternative Name:Qinghaosu
 
Formula:C15H22O5
 
MW:282.4
 
Source:Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.
 
CAS:63968-64-9
 
MI:14: 817
 
RTECS:KD4170000
 
Purity:≥98% (TLC)
 
Identity:Determined by IR.
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO or acetone; almost insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
ALX-350-219
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ALX-350-219

Product Literature References

From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006), Review, Abstract;
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), Review, Abstract;
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003), Abstract;
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003), Abstract;
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Review, Abstract;
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994),
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987), Abstract;
Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985), Abstract;

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