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Alternariol monomethyl ether

Topoisomerase IIα inhibitor
 
ALX-350-170-M001 1 mg 410.00 USD
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Mycotoxin contaminant of fruit and cereal products. Exhibits antifungal and phytotoxic activity. Has also been shown to possess DNA strand-breaking activity and inhibits the activity of topoisomerase IIα in mammalian cell models.

Product Specification

Alternative Name:9-O-Methylalternariol, Djalonensone, AME, 3,7-Dihydroxy-9-methoxy-1-methyl-6H- dibenzo[b,d]pyran-6-one
 
Formula:C15H12O5
 
MW:272.3
 
Source:Isolated from Alternaria sp.
 
CAS:26894-49-5
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Off-white to light brown solid.
 
Solubility:Soluble in methylene chloride, dichloromethane or methanol.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:After reconstitution protect from light at -20°C.
 
350-170
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350-170

Product Literature References

Alternariol acts as a topoisomerase poison preferentially affecting the IIα isoform.: M. Fehr et al.; Mol. Nutr. Food Res. 53, 441 (2009), Abstract;
Analysis of alternariol and alternariol monomethyl ether on flavedo and albedo tissues of tangerines (Citrus reticulata) with symptoms of alternaria brown spot.: R. F. Magnani, et al; J. Agric. Food Chem. 55, 4980 (2007), Abstract;
Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether: E. Pfeiffer, et al.; Mol. Nutr. Food Res. 51, 307 (2007), Abstract;
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium: V.M. Davis and M.E. Stack; Appl. Environ. Microbiol. 60, 3901 (1994), Abstract; Full Text
Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay: G.F. Griffin and F.S. Chu; Appl. Environ. Microbiol. 46, 1420 (1983), Abstract; Full Text
Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata: K. Soderhall, et al.; Appl. Environ. Microbiol. 36, 655 (1978), Abstract; Full Text
Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis: H. Raistrick, et al.; Biochem. J. 55, 421 (1953), Abstract; Full Text

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