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Aloesin

Tyrosinase inhibitor
 
ALX-350-158-M001 1 mg 133.00 USD
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C-glycosylated chromone compound. Competitive inhibitor of tyrosinase. Shows weak free radical scavenging activity. Anti-inflammatory. Modulates melanogenesis (pigmentation-altering agent). Used in the cosmetic industry.

Product Specification

Alternative Name:Aloeresin B, NSC 631262, 8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
 
Formula:C19H22O9
 
MW:394.4
 
Source:Isolated from Aloe sp.
 
CAS:30861-27-9
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by 1H-NMR and MS.
 
Appearance:Pale yellow to brown powder.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
350-158
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350-158

Product Literature References

Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007), Abstract;
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005), Abstract;
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002), Abstract;
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002), Abstract;
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002), Abstract;
Mushroom tyrosinase inhibition activity of some chromones: L.Z. Piao, et al.; Chem. Pharm. Bull. (Tokyo) 50, 309 (2002), Abstract;
Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997), Abstract;
Chromones in aloe species. I. Aloesin--a C-glucosyl-7-hydroxychromone: D.K. Holdsworth; Planta Med. 19, 322 (1971), Abstract;
The distribution of aloesin in some South African Aloe species: T.J. McCarthy & L.J. Haynes; Planta Med. 15, 342 (1967), Abstract;

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