Microcystin-LY



ALX-350-148-C025	25 µg	147.00 USD

ALX-350-148-C100	100 µg	422.00 USD

Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Arg. Its toxicity is intermediate between the more toxic microcystin-LF and the less toxic microcystin-LR.

Product Specification

Identity:	Identity determined by MS.

Formula:	C₅₂H₇₁N₇O₁₃

MW:	1002.2

Purity:	≥95% (HPLC)

Appearance:	Whitish film adhered to inside of the vial.

CAS:	123304-10-9

Source/Host:	Isolated from Microcystis aeruginosa.

Solubility:	Soluble in 100% ethanol or methanol.

Long Term Storage:	-20°C

Use/Stability:	Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.

Hazard:	HIGHLY IRRITANT. MAY BE CARCINOGENIC. VERY TOXIC.

Handling:	For maximum product recovery after thawing, centrifuge the vial before opening the cap.

Background / Technical Information:	Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala¹-X²-D-MeAsp³-Y⁴-Adda⁵-D-Glu⁶-Mdha⁷-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-ß-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C₂₀ ß-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

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Product Literature References

Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999), Abstract;

Identification and characterization of microcystin-LY from Microcystis aeruginosa (strain 298): S. Rudolph-Bohner, et al.; Biol. Chem. Hoppe Seyler 374, 635 (1993), Abstract;

The effects of single L-amino acid substitutions on the lethal potencies of the microcystins: R.D. Stoner, et al.; Toxicon 27, 825 (1989),