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Rocaglamide I

NF-κB inhibitor
ALX-350-142-C050 50 µg 111.00 USD
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Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.

Product Specification

Alternative Name:1-Acetyl-3’-hydroxyrocaglamide
Source:Isolated from Aglaia sp.
Purity:≥97% (HPLC)
Identity:Identity determined by MS, 1H-NMR.
Appearance:White to off-white sticky solid.
Solubility:Soluble in DMSO or 100% ethanol.
Long Term Storage:-20°C
Handling:Protect from light.
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Product Literature References

Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006), Abstract;
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006), Abstract;
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005), Abstract; Full Text
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002), Abstract; Full Text
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001), Abstract;
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001), Abstract;
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000), Abstract;
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000), Abstract;
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982),

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