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Hexaprenylhydroquinone

Inhibitor of Reverse transcriptase and DNA polymerase
 
ALX-350-138-M001 1 mg 112.00 USD
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Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.

Product Specification

Alternative Name:HPH
 
Formula:C36H54O2
 
MW:518.8
 
Source:Isolated from Sarcotragus sp.
 
CAS:119980-00-6
 
Purity:≥97% (HPLC)
 
Identity:Determined by MS, 1H-NMR.
 
Appearance:Off-white to brown solid. May appear as oily solid.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
350-138
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350-138

Product Literature References

Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A: I. Erdogan-Orhan, et al.; Nat. Prod. Res. 18, 1 (2004), Abstract;
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases: S. Loya, et al.; Biochem. J. 324, 721 (1997), Abstract; Full Text
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays: S. De Rosa, et al.; J. Nat. Prod. 57, 1711 (1994), Abstract;
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata: Y. Venkateswarlu & M. Venkata Rami Reddy; J. Nat. Prod. 57, 1286 (1994), Abstract;

General Literature References

Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses: B. Gil, et al.; Eur. J. Pharmacol. 285, 281 (1995), Abstract;

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