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Pyripyropene A

ACAT2 inhibitor
 
ALX-350-134-C500 500 µg 211.00 USD
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Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2).

Product Specification

Alternative Name:(+)-Pyripyropene A, PPPA
 
Formula:C31H37NO10
 
MW:583.6
 
Source:Isolated from Aspergillus fumigatus FO-1289.
 
CAS:147444-03-9
 
Purity:≥85% (HPLC)
 
Appearance:White to brown powder.
 
Solubility:Soluble in DMSO,chloroform, methanol or ethyl acetate; insoluble in water or hexane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Manufacturer:Fungal strain courtesy of The Kitasato Institute, Tokyo.
 
350-134
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350-134

Product Literature References

Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007), Abstract;
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A: J. Justicia, et al.; J. Org. Chem. 70, 8265 (2005), Abstract;
Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites: T. Sunazuka and S. Omura; Chem. Rev. 105, 4559 (2005), Abstract;
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver: P. Parini, et al.; Circulation 110, 2017 (2004), Abstract; Full Text
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness: A.T. Lada, et al.; J. Lipid Res. 45, 378 (2004), Abstract; Full Text
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation: K.H. Cho, et al.; BBRC 309, 864 (2003), Abstract;
A formal synthesis of (+)-pyripyropene A using a biomimetic epoxy-olefin cyclisation: effect of epoxy alcohol/ether on cyclisation efficiency: V.K. Aggarwal, et al.; J. Chem. Soc. 3315 (1999), Full Text
Meroterpenoids with various biological activities produced by fungi: K. Shiomi, et al.; Pure Appl. Chem. 71, 1059 (1999), Full Text
Biosynthesis of Pyripyropene A: H. Tomoda, et al.; J. Org. Chem. 61, 882 (1996),
Aflavinines and other antiinsectan metabolites from the ascostromata of Eupenicillium crustaceum and related species: H.J. Wang, et al.; Appl. Environ. Microbiol. 61, 4429 (1995), Abstract; Full Text
Total Synthesis of (+)-Pyripyropene A, a Potent, Orally Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase: T. Nagamitsu, et al.; J. Org. Chem. 60, 8126 (1995),
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties: H. Tomoda, et al.; J. Antibiot. 47, 148 (1994), Abstract;
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D: Y.K. Kim, et al.; J. Antibiot. 47, 154 (1994), Abstract;
Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus: S. Omura, et al.; J. Antibiot. 46, 1168 (1993), Abstract;

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