Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin (Prod. No. ALX-350-015). Used in chemotherapy of several different cancers.
Product Details
| Alternative Name: | 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin . HCl |
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| Formula: | C23H23N3O5 . HCl |
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| MW: | 458 |
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| Source: | Semisynthetic. |
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| CAS: | 119413-54-6 |
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| MI: | 14: 9548 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Light yellow to greenish powder. |
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| Solubility: | Soluble in water (1mg/ml) or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair in Drosophila melanogaster: A. Thomas, et al.; Genes
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Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol.
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Abstract;
Topotecan for the treatment of small-cell lung cancer: S.J. Nicum & M.E. O´Brien; Expert Rev. Anticancer Ther.
7, 795 (2007),
Abstract;
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues: B. Arun & E.P. Frenkel; Expert Opin. Pharmacother.
2, 491 (2001), Review,
Abstract;
Clinical status and optimal use of topotecan: C.H. Takimoto & S.G. Arbuck; Oncology (Williston Park)
11, 1635 (1997), Review,
Abstract;
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells: F.M. Uckun, et al.; Blood
85, 2817 (1995),
Abstract;
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity: W.D. Kingsbury, et al.; J. Med. Chem.
34, 98 (1991),
Abstract;
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