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Topotecan . hydrochloride

Topoisomerase I inhibitor
 
ALX-350-133-M001 1 mg 36.00 USD
 
ALX-350-133-M005 5 mg 99.00 USD
 
ALX-350-133-M025 25 mg 378.00 USD
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Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin (Prod. No. ALX-350-015). Used in chemotherapy of several different cancers.

Product Specification

Alternative Name:9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin . HCl
 
Formula:C23H23N3O5 . HCl
 
MW:458
 
Source:Semisynthetic.
 
CAS:119413-54-6
 
MI:14: 9548
 
Purity:≥98% (HPLC)
 
Appearance:Light yellow to greenish powder.
 
Solubility:Soluble in water (1mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-133
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350-133

Product Literature References

Topotecan for the treatment of small-cell lung cancer: S.J. Nicum & M.E. O´Brien; Expert Rev. Anticancer Ther. 7, 795 (2007), Abstract;
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues: B. Arun & E.P. Frenkel; Expert Opin. Pharmacother. 2, 491 (2001), Review, Abstract;
Clinical status and optimal use of topotecan: C.H. Takimoto & S.G. Arbuck; Oncology (Williston Park) 11, 1635 (1997), Review, Abstract;
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells: F.M. Uckun, et al.; Blood 85, 2817 (1995), Abstract;
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity: W.D. Kingsbury, et al.; J. Med. Chem. 34, 98 (1991), Abstract;

Related Products

(S)-(+)-Camptothecin 

Potent antitumor agent
7689-03-4, Isolated from Mappia foetida Miers (Nothapodytes foetida (Wt.) Sleumer)., ≥98% (HPLC) | Print as PDF
 
ALX-350-015-M050 50 mg 53.00 USD
 
ALX-350-015-M250 250 mg 182.00 USD
 
ALX-350-015-G001 1 g 397.00 USD
Do you need bulk/larger quantities?
 

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