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Tentoxin

F-ATPase inhibitor
 
ALX-350-132-MC05 0.5 mg 199.00 USD
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Cyclic tetrapeptide. Inhibitor of chloroplast F1-ATPase (CF1). Does not inhibit the homologous enzymes from chloroplasts of insusceptible plant species or from bacteria or mitochondria.

Product Specification

Alternative Name:cyclo-(N-Methyl-L-alanyl-L-leucyl-N-methyl-(Z)-dihydrophenylalanyl-glycyl)
 
Formula:C22H30N4O4
 
MW:414.5
 
Source:Isolated from Alternaria alternata.
 
CAS:28540-82-1
 
Purity:≥98% (HPLC, TLC)
 
Purity Detail:Free of any peptide contaminations, especially dihydrotentoxin.
 
Appearance:Off-white to yellow powder.
 
Solubility:Soluble in DMSO (10mg/ml) or methanol (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
350-132
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350-132

Product Literature References

Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase: Arch. Toxicol.; J. Kim, et al. 1 (2016), Application(s): Impact on the activity of human and bacterial topo II., Abstract;
Complete inhibition and partial Re-activation of single F1-ATPase molecules by tentoxin: new properties of the re-activated enzyme: P. Pavlova, et al.; J. Biol. Chem. 279, 9685 (2004), Abstract; Full Text
Metabolism of tentoxin by hepatic cytochrome P-450 3A isozymes: M. Delaforge, et al.; Eur. J. Biochem. 250, 150 (1997), Abstract;
Effects of tentoxin and dihydrotentoxin on human erythrocytes: K. Gwozdzinski, et al.; Cytobios. 67, 183 (1991), Abstract;

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