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SIRT inhibitor
ALX-350-129-M001 1 mg 221.00 USD
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Stable and water-soluble derivative of hyperforin inducing apoptosis. Antitumor agent. Inhibits sirtuins.

Product Specification

Identity:Identity determined by MS, 1H- and 13C-NMR.
Appearance:White to yellow oil.
Solubility:Soluble in DMSO or 100mM sodium hydrogen carbonate/2% DMSO.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Handling:Protect from light.
ALX-350-129 structure
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ALX-350-129 structure

Product Literature References

Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells: M. Šemeláková, et al.; Biomed. Pharmacother. 81, 38 (2016), Application(s): Cell culture, Abstract;
DNA-protective activities of hyperforin and aristoforin: A. Ševčovičová, et al.; Toxicol. In Vitro 29, 631 (2015), Application(s): Assay, Abstract;
Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2: C. Gey, et al.; Angew. Chem. Int. Ed. Engl. 46, 5219 (2007), Abstract;
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent: M. Gartner, et al.; Chembiochem. 6, 171 (2005), Abstract;

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