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Chetomin

HIF-1 inhibitor
 
ALX-350-128-M001 1 mg 161.00 USD
 
ALX-350-128-M005 5 mg 630.00 USD
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Dithiodiketopiperazine inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α. Inhibitor of tumor growth. Potent immunosuppressor. Antibacterial.

Product Specification

Alternative Name:Chaetomin
 
Formula:C31H30N6O6S4
 
MW:710.9
 
Source:Isolated from Chaetomium species.
 
CAS:1403-36-7
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Off-white to fawn solid.
 
Solubility:Soluble in DMSO, ethyl acetate or pyridine; fairly soluble in methanol, 100% ethanol; insoluble in water.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:Following reconstitution in highly pure, anhydrous solvent, aliquot and freeze at -80°C. Protect from light and moisture. Avoid freeze/thaw cycles.
 
350-128
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350-128

Product Literature References

Lipopolysaccharide induces inducible nitric oxide synthase-dependent podocyte dysfunction via a hypoxia-inducible factor 1-alpha and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathway: A.K. Mashmoushi, et al.; Free Radic. Biol. Med. 84, 185 (2015), Application(s): Cell Culture, Abstract;
Hypoxia-inducible factors promote alveolar development and regeneration: A. Vadivel, et al.; Am. J. Respir. Cell Mol. Biol. 50, 96 (2014), Abstract;
Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells: K. Yano, et al.; Int. J. Oncol. 38, 365 (2011), Abstract;
Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells: A. Staab, et al.; BMC Cancer 7, 213 (2007), Abstract; Full Text
Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum: H. Fujimoto, et al.; J. Nat. Prod. 67, 98 (2004), Abstract;
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway: A.L. Kung, et al.; Cancer Cell 6, 33 (2004), Abstract;
Effects of chetomin on growth and acidic fermentation products of rumen bacteria: W.C. Jen and G.A. Jones; Can. J. Microbiol. 29, 1399 (1983), Abstract;
The structure of chetomin: A.G. McInnes, et al.; JACS 98, 6741 (1976), Abstract;

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