Mycotoxin. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
Product Details
Alternative Name: | FTC, SM-Q |
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Formula: | C22H25N3O3 |
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MW: | 379.5 |
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Source: | Isolated from Aspergillus fumigatus. |
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CAS: | 118974-02-0 |
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Purity: | ≥96% (HPLC) |
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Identity: | Determined by 1H-NMR. |
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Appearance: | White to light brown powder. |
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Solubility: | Soluble in DMSO, methanol or chloroform. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | +4°C |
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Technical Info/Product Notes: | Optical Rotation: [α]D= +19° ±1° (c=1.0 in methanol). |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma: W.J. Ingram, et al.; Exp. Hematol. Oncol.
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Abstract;
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Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2: K. Takabe, et al.; J. Biol. Chem.
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Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941: L. Salphati, et al.; Drug. Metab. Dispos.
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The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells: Y. Ma & M. Wink; Phytother. Res.
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Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes: S. Hauswald, et al.; Clin. Cancer Res.
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Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors: T.S. Garimella, et al.; Cancer Chemother. Pharmacol.
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Abstract;
The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res.
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Abstract;
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Abstract;
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.: S.K. Rabindran, et al.; Cancer Res.
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Abstract;
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin: S.K. Rabindran, et al.; Cancer Res.
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Abstract;
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot.
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Abstract;
Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage: R.J. Cole, et al.; J. Agric. Food Chem.
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