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Fumitremorgin C

BCRP inhibitor
 
ALX-350-127-C250 250 µg 420.00 USD
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Mycotoxin. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.

Product Specification

Alternative Name:FTC, SM-Q
 
Formula:C22H25N3O3
 
MW:379.5
 
Source:Isolated from Aspergillus fumigatus.
 
CAS:118974-02-0
 
Purity:≥96% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to light brown powder.
 
Solubility:Soluble in DMSO, methanol or chloroform.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Technical Info/Product Notes:Optical Rotation: [α]D= +19° ±1° (c=1.0 in methanol).
 
350-127
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350-127

Product Literature References

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2: K. Takabe, et al.; J. Biol. Chem. 285, 10477 (2010), Abstract;
Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941: L. Salphati, et al.; Drug. Metab. Dispos. 38, 1422 (2010), Abstract;
The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells: Y. Ma & M. Wink; Phytother. Res. 24, 146 (2010), Abstract;
Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes: S. Hauswald, et al.; Clin. Cancer Res. 15, 3705 (2009), Abstract;
Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors: T.S. Garimella, et al.; Cancer Chemother. Pharmacol. 55, 101 (2005), Abstract;
The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003), Abstract;
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.: Ozvegy, et al.; J. Biol. Chem. 277, 47980 (2002), Abstract;
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.: S.K. Rabindran, et al.; Cancer Res. 60, 47 (2000), Abstract;
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin: S.K. Rabindran, et al.; Cancer Res. 58, 5850 (1998), Abstract;
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot. 49, 527 (1996), Abstract;
Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage: R.J. Cole, et al.; J. Agric. Food Chem. 25, 826 (1977), Abstract;

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