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Ferulenol

 
ALX-350-124-M001 1 mg 49.00 USD
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Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.

Product Specification

Formula:C24H30O3
 
MW:366.5
 
Source:Isolated from Ferula communis.
 
CAS:6805-34-1
 
Purity:≥96% (HPLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
350-124
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350-124

Product Literature References

Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007), Abstract;
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002), Abstract;
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002), Abstract;
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998),
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994), Abstract;
Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989), Abstract;

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