Deguelin - Enzo Life Sciences

ALX-350-118

Revised 01-Feb-10

Deguelin
SYNONYMS	[-]-Deguelin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-118-M005		5 mg	60.00 USD
ALX-350-118-M025		25 mg	240.00 USD
Replaces Prod. #: BML-EI329

Product Specification

FORMULA:	C₂₃H₂₂O₆
MW:	394.4
CAS NUMBER:	522-17-8
MERCK INDEX:	14: 2863
RTECS:	DX1500000
PURITY:	≥95%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in acetone, acetonitrile, DMSO (25mg/ml) or 100% ethanol (25mg/ml). Insoluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Premalignant and malignant human brochial epithelial cells are highly sensitive to deguelin compared to normal cells. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.

Product Specific Literature References

Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid: G.O. Udeani et al.; Cancer. Res. 57, 3424 (1997) Abstract
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest: G. Murillo, et al.; Eur. J. Cancer 38, 2446 (2002) Abstract
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells: K.H. Chun, et al.; J. Natl. Cancer Inst. 95, 291 (2003) Abstract; Full Text
Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata: C. Ito, et al.; Planta Med. 70, 8 (2004) Abstract
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.: N. Hail, et al.; Apoptosis 9, 437 (2004) Abstract
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells: H.Y. Lee, et al.; Clin. Cancer Res. 10, 1074 (2004) Abstract
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells: H.Y. Lee; Biochem. Pharmacol 68, 1119 (2004) Abstract

Further Categories Containing This Product:

COX Inhibitors • Akt [PKB] / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Apoptosis Inducers & Inhibitors • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Antitumor Agents (Apoptosis Inducers)