Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Sauchinone

Cytoprotective and antioxidant
 
ALX-350-116-M005 5 mg 222.00 USD
Do you need bulk/larger quantities?
 
Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.

Product Specification

Formula:C20H20O6
 
MW:356.1
 
Source:Isolated from Saururus chinensis.
 
CAS:177931-17-8
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or chloroform.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
350-116
Please mouse over
350-116

Product Literature References

Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007), Abstract;
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003), Abstract;
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003), Abstract;
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003), Abstract;
Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000), Abstract;
Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000), Abstract;

Related Products

Staurosporine 

Apoptosis inducer. Protein kinase inhibitor.
62996-74-1, Isolated from Streptomyces staurosporeus., ≥99% (HPLC) | Print as PDF
 
ALX-380-014-C100 100 µg 57.00 USD
 
ALX-380-014-C250 250 µg 110.00 USD
 
ALX-380-014-M001 1 mg 276.00 USD
 
ALX-380-014-M005 5 mg 386.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2020 Enzo Life Sciences, Inc.,