Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Sauchinone

Cytoprotective and antioxidant
 
ALX-350-116-M001 1 mg 48.00 USD
 
ALX-350-116-M005 5 mg 212.00 USD
Do you need bulk/larger quantities?
 
Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.

Product Specification

Formula:C20H20O6
 
MW:356.1
 
Source:Isolated from Saururus chinensis.
 
CAS:177931-17-8
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or chloroform.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
350-116
Please mouse over
350-116

Product Literature References

Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007), Abstract;
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003), Abstract;
Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003), Abstract;
Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003), Abstract;
Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000), Abstract;
Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000), Abstract;

Related Products

Staurosporine 

Apoptosis inducer. Protein kinase inhibitor.
62996-74-1, Isolated from Streptomyces staurosporeus., ≥99% (HPLC) | Print as PDF
 
ALX-380-014-C100 100 µg 53.00 USD
 
ALX-380-014-C250 250 µg 102.00 USD
 
ALX-380-014-M001 1 mg 255.00 USD
 
ALX-380-014-M005 5 mg 357.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,