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NF-κB pathway inhibitor
ALX-350-109-MC05 0.5 mg 480.00 USD
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Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.

Product Specification

Source:Isolated from Lentinus crinitus.
Purity:≥95% (HPLC, MS)
Appearance:Yellow oil.
Solubility:Soluble in DMSO, 100% ethanol or methanol.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Handling:Protect from light. Keep cool and dry. After reconstitution, prepare aliquots and store at -20°C.
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Product Literature References

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus: R.E. Watkinson, et al.; PLoS Pathog. 11, e1005253 (2015), Application(s): NF-κB inhibitor, Abstract; Full Text
Tumor necrosis factor (TNF)-alpha upregulates progesterone receptor-A by activating the NF-kappaB signaling pathway in human decidua after labor onset: Z.Y. Jiang, et al.; Placenta 33, 1 (2012), Abstract;
Activation of cytokine expression occurs through the TNFalpha/NF-kappaB-mediated pathway in birnavirus-infected cells: W.L. Wang, et al.; Fish Shellfish Immunol. 31, 10 (2011), Abstract;
Regulation of glycosyltransferases and Lewis antigens expression by IL-1beta and IL-6 in human gastric cancer cells: M. Padro, et al.; Glycoconj. J. 28, 99 (2011), Abstract;
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007), Abstract;
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter: M. Ramanathan, et al.; Mol. Biol. Cell 18, 14 (2007), Abstract; Full Text
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002), Abstract;
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002), Abstract;
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000), Abstract;
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998), Abstract;
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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