Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Hellebrin

Na+/K+ ATPase inhibitor
 
ALX-350-105-M005 5 mg 222.00 USD
Do you need bulk/larger quantities?
 
Cardiotonic glycoside which presents a bufadienolide-steroid structure. Besides ouabain (Prod. No. ALX-350-066), from the class of cardenolides hellebrin is the second unique water soluble cardiotonic glycoside. Extremely potent inhibitor of Na+/K+-ATPase (sodium pump) blocking the active efflux of Na+ and reuptake of K+ of this membrane enzyme. Shows a positive inotropic effect by increasing the intracellular Ca2+ concentration. Strong immunosuppressor inhibiting T cell activity with much higher potency than cortisol or cyclosporin A (Prod. No. BML-A195). Induces caspase-dependent apoptosis.

Product Specification

Alternative Name:3β-(O4-β-D-Glucopyranosyl-α-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14-β-bufa-20,22-dienolide
 
Formula:C36H52O15
 
MW:724.8
 
Source:Isolated from Helleborus sp.
 
CAS:13289-18-4
 
Purity:≥99% (HPLC, TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (4.4mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-105
Please mouse over
350-105

Product Literature References

Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives: D. Daniel, et al.; Int. Immunopharmacol. 3, 1791 (2003), Abstract;
Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response: P. Terness, et al.; Transplant Proc. 33, 547 (2001), Abstract;
In search of ideal inotropic steroids: recent progress: K.R. Repke, et al.; Prog. Drug Res. 47, 9 (1996), Abstract;
The structure of hellebrin: P. Muhr, et al.; Liebigs Ann. Org. Bioorg. Chem. 2, 443 (1995),
Über Hellebrin, ein krystallisiertes Glykosid aus Radix Hellebori nigri: W. Karrer; Helv. Chim. Acta 26, 1353 (1943),

Related Products

Ouabain . octahydrate 

Na+/K+ ATPase inhibitor
11018-89-6, ≥98% (TLC) | Print as PDF
 
ALX-350-066-M100 100 mg 34.00 USD
Do you need bulk/larger quantities?
 

Cyclosporin A 

Immunosuppressant
59865-13-3, Isolated from Fusarium solani, ≥98% (Assay) | Print as PDF
 
BML-A195-0100 100 mg 59.00 USD
 
BML-A195-0500 500 mg 234.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,