Aaptamine

Adrenergic receptor inhibitor



ALX-350-104-M001	1 mg	59.00 USD

Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Inhibitor of sortase A (SrtA) IC₅₀=23.5 µg/ml. Minimum inhibitory concentration (MIC) on S. aureus >200µg/ml.
Proteasome (chymotrypsin-like) inhibitor IC₅₀=1,6µg/ml.

Product Specification

Alternative Name:	8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine

Formula:	C₁₃H₁₂N₂O₂

MW:	228.3

Purity:	≥97%

Appearance:	Oil.

CAS:	85547-22-4

Source/Host:	Isolated from the sponge Aaptos aaptos.

Solubility:	Soluble in DMSO or 100% ethanol.

Long Term Storage:	-20°C

Hazard:	TOXIC.

Handling:	Protect from light.

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Product Literature References

Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor: S. Tsukamoto, et al.; Bioorg. Med. Chem. Lett. 20, 3341 (2010), Abstract;

Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos: K.H. Jang, et al.; Bioorg. Med. Chem. Lett. 17, 5366 (2007), Abstract;

Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner: S. Aoki, et al.; BBRC 342, 101 (2006), Abstract;

Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine: G.R. Pettit, et al.; J. Org. Chem. 69, 2251 (2004), Abstract;

Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle: Y. Ohizumi, et al.; J. Pharm. Pharmacol. 36, 785 (1984), Abstract;