Lacks physiological activity itself, but is contained as the pentacyclic moiety in the antineoplastic agents vinblastine and vincristine.
Product Details
| Alternative Name: | (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-Aspidospermidine-3-carboxylic acid methyl ester |
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| Formula: | C25H32N2O6 |
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| MW: | 456.5 |
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| Source: | Isolated from Catharanthus roseus. |
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| CAS: | 2182-14-1 |
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| MI: | 14: 9988 |
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| RTECS: | CJ0120000 |
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| Purity: | ≥90% (assay on dried basis) |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in 100% ethanol and water (30mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Very hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Catharanthus roseus L. plants and explants infected with phytoplasmas: alkaloid production and structural observations: M.A. Favali, et al.; Protoplasma
223, 45 (2004),
Abstract;
Antimitotic agents: chemistry and recognition of tubulin molecule: S. Iwasaki; Med. Res. Rev.
13, 183 (1993),
Abstract;
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry
30, 873 (1991),
Abstract;
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol.
51, 515 (1990),
Abstract;
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