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Ferutinin (high purity)

Estrogen receptor α activator
 
ALX-350-098-M005 5 mg 111.00 USD
 
ALX-350-098-M010 10 mg 199.00 USD
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Potent, naturally occuring non-steroid estrogenic compound. Agonist for estrogen receptor (ER) α and agonist/antagonist for ERβ with higher binding affinity than tamoxifen (Prod. No. ALX-550-095) for both ERs. Electrogenic Ca2+ ionophore inducing mitochondrial depolarisation which can be completely blocked by cyclosporin A (Prod. No. BML-A195), suggesting that ferutinin opens the mitochondrial permeability transition pore (mPTP). In a concentration range of 1-50µM ferutinin increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes for Ca2+.

Product Specification

Formula:C22H30O4
 
MW:358.5
 
Source:Semisynthetic.
 
CAS:41743-44-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid
 
Solubility:Soluble in acetone, dichloromethane, DMSO or ethyl acetate.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-350-098
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ALX-350-098

Product Literature References

Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003), Abstract;
Daucane phytoestrogens: a structure-activity study: G. Appendino, et al.; J. Nat. Prod. 65, 1612 (2002), Abstract;
Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002), Abstract;
Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers: A.Y. Abramov, et al.; Biochim. Biophys. Acta 1512, 98 (2001), Abstract;
Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997), Abstract;
Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973),

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