Berberine . hemisulfate



ALX-350-094-G001	1 g	10.00 USD

Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects.

Alternative Name:	Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium

Identity:	Determined by IR: Identical to standard reference.

Formula:	C₂₀H₁₈NO₄. 0.5SO₄

MW:	336.4 . 48.0

Purity:	≥98% (TLC)

Appearance:	Off-white to yellow powder.

CAS:	633-66-9

MI:	14: 1154

RTECS:	DR9867000

Solubility:	50mg/ml soluble in methanol:water 2:1.

Long Term Storage:	+20°C

Hazard:	TOXIC.

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Product Literature References

Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine: I.M. Al-masri, et al.; J. Enzyme Inhib. Med. Chem. 24, 1061 (2009), Abstract;

Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway: L. Zhou, et al.; Endocrinology (2008), Abstract;

Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.: M.K. Pandey, et al.; Cancer Res. 68, 5370 (2008), Abstract;

Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3: C.C. Lin, et al.; Anticancer Res. 26, 227 (2006), Abstract;

Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation: Y. Bustanji, et al.; J. Enzyme Inhib. Med. Chem. 21, 163 (2006), Abstract;

Berberine inhibits HIF-1alpha expression via enhanced proteolysis: S. Lin, et al.; Mol. Pharmacol. 66, 612 (2004), Abstract;

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins: W. Kong, et al.; Nat. Med. 10, 1344 (2004), Abstract;

The anti-inflammatory potential of berberine in vitro and in vivo: C.L. Kuo, et al.; Cancer Lett. 203, 127 (2004), Abstract;

Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion: S.H. Leng, et al.; Acta Pharmacol. Sin. 25, 496 (2004), Abstract;

Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor: F.R. Stermitz, et al.; PNAS 97, 1433 (2000), Abstract; Full Text

Bacteria lacking a multidrug pump: a sensitive tool for drug discovery: P.C. Hsieh, et al.; PNAS 95, 6602 (1998), Abstract; Full Text

Berberine sulfate: antimicrobial activity, bioassay, and mode of action: A.H. Amin, et al.; Can. J. Microbiol. 15, 1067 (1969), Abstract;