Emetine . dihydrochloride



ALX-350-092-M050	50 mg	7.00 USD

Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.

Product Specification

Alternative Name:	6’,7’,10,11-Tetramethoxyemetan . 2HCl

Formula:	C₂₉H₄₀N₂O₄ . 2HCl

MW:	480.7 . 73.0

Purity:	≥98%

Appearance:	White to off-white solid.

CAS:	316-42-7

MI:	14: 3559

Source/Host:	Isolated from ground roots of Uragoga ipecacuanha.

Solubility:	Soluble in water or 100% ethanol.

Long Term Storage:	+4°C

Hazard:	TOXIC.

Handling:	Protect from light. Hygroscopic.

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Product Literature References

Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007), Abstract;

The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007), Abstract;

Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005), Abstract;

Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995), Abstract;

Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991), Abstract;

Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991), Abstract;

Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968), Abstract;