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Emetine . dihydrochloride

ALX-350-092-M050 50 mg 31.00 USD
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Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.

Product Specification

Alternative Name:6’,7’,10,11-Tetramethoxyemetan . 2HCl
Formula:C29H40N2O4 . 2HCl
MW:480.6 . 72.9
Source:Isolated from ground roots of Uragoga ipecacuanha.
MI:14: 3559
Purity:≥98% (Perchloric Acid Titration)
Appearance:White to off-white solid.
Solubility:Soluble in water or 100% ethanol.
Long Term Storage:+4°C
Handling:Protect from light. Hygroscopic.
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Product Literature References

Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007), Abstract;
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007), Abstract;
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005), Abstract;
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995), Abstract;
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991), Abstract;
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991), Abstract;
Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968), Abstract;

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