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Sanguinarine chloride

Na+/K+- and Mg2+-ATPase inhibitor
 
ALX-350-076-M005 5 mg 173.00 USD
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Na+/K+-and Mg2+-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.

Product Specification

Alternative Name:Pseudochelerythrine
 
Formula:C20H14NO4Cl
 
MW:367.8
 
Source:Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
 
CAS:5578-73-4
 
MI:14: 8356
 
RTECS:VP5220000
 
Purity:≥98% (HPLC)
 
Appearance:Orange solid.
 
Solubility:Soluble in methanol; slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-350-076 structure
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ALX-350-076 structure

Product Literature References

Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs 18, 913 (2007), Abstract;
Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab. 8, 173 (2007), Review, Abstract;
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 538 (2006), Abstract;
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract;
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes: V.M. Adhami, et al.; Clin. Cancer Res. 9, 3176 (2003), Abstract;
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion: E. Debiton, et al.; Cancer Chemother. Pharmacol. 51, 474 (2003), Abstract;
Sanguinarine, a new antiplaque agent: retention and plaque specificity: G.L. Southard, et al.; J. Am. Dent. Assoc. 108, 338 (1984), Abstract;
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases: L.R. Meyerson, et al.; Neurochem. Res. 3, 239 (1978), Abstract;
Sanguinarine, inhibitor of Na-K dependent ATP'ase: K.D. Straub & P. Carver; BBRC 62, 913 (1975), Abstract;

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