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Okadaol

 
ALX-350-065-C100 100 µg 412.00 USD
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Derived from okadaic acid by reduction of the carboxyl group. Inactive against protein phosphatases.

Product Specification

Formula:C44H70O12
 
MW:791.1
 
Source:Semisynthetic derivative of okadaic acid. Okadaic acid isolated from Prorocentrum lima.
 
CAS:131959-12-1
 
Purity:≥90%
 
Appearance:Colorless solid.
 
Solubility:Soluble in methanol or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
350-065
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350-065

Product Literature References

The total activity of a mixture of okadaic acid-group compounds can be calculated by those of individual analogues in a phosphoprotein phosphatase 2a assay: C. Albano, et al.; Toxicon 53, 631 (2009), Abstract;
Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung: R. Bastan, et al.; Eur. J. Pharmacol. 430, 135 (2001), Abstract;
An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures: J.S. Sidhu & C.J. Omiecinski; J. Pharmacol. Exp. Ther. 282, 1122 (1997), Abstract;
Preliminary characterization of the role of protein serine/threonine phosphatases in the regulation of human lung mast cell function: M.J. Peirce, et al.; Br. J. Pharmacol. 120, 239 (1997), Abstract;
Regulation of human basophil function by phosphatase inhibitors: M.J. Peirce, et al.; Br. J. Pharmacol. 119, 446 (1996), Abstract;
Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases: R.E. Honkanen, et al.; Toxicon 32, 339 (1994), Abstract;
Regulation of human lung mast cell function by phosphatase inhibitors: P.T. Peachell & M.R. Munday; J. Immunol. 151, 3808 (1993), Abstract;

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