Curcumin (high purity)

Inhibitor of Lipoxygenase and COX



ALX-350-028-M010	10 mg	27.00 USD

ALX-350-028-M050	50 mg	72.00 USD

ALX-350-028-M250	250 mg	257.00 USD

Replaces Prod. #: BML-EI135

Dual inhibitor of 5-lipoxygenase (IC₅₀=8µM) and cyclooxygenase (COX) (IC₅₀=52µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.

Alternative Name:	1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane

Formula:	C₂₁H₂₀O₆

MW:	368.4

Purity:	≥98.5% (Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities)

Appearance:	Orange-yellow crystalline powder.

CAS:	458-37-7

MI:	14: 2673

Source/Host:	Isolated from turmeric (Curcuma longa).

Solubility:	Soluble in acetic acid, 100% ethanol (10mg/ml) or DMSO (25mg/ml).

Long Term Storage:	+20°C

Handling:	Protect from light.

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Product Literature References

The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats: T. Morimoto, et al.; J. Clin. Invest. 118, 868 (2008), Abstract; Full Text

Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species: M. Panchatcharam, et al.; Mol. Cell Biochem. 290, 87 (2006), Abstract;

Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1: M.K. Bae, et al.; Oncol. Rep. 15, 1557 (2006), Abstract;

Curcumin is an inhibitor of p300 histone acetylatransferase: M.G. Marcu, et al.; Med. Chem. 2, 169 (2006), Abstract;

Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases: S. Bengmark; JPEN J. Parenter. Enteral. Nutr. 30, 45 (2006), (Review), Abstract;

Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia: K.K. Jung, et al.; Life Sci. 79, 2022 (2006), Abstract;

Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006), (Review), Abstract;

Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells: Z. Wang, et al.; Cancer 106, 2503 (2006), Abstract;

Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin: B.S. Park, et al.; J.Agric.Food Chem. 53, 9005 (2005), Abstract;

Immunomodulatory effects of curcumin: V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol. 27, 485 (2005), Abstract;

Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin: P. Tsvetkov, et al.; PNAS 102, 5535 (2005), Abstract;

Biological properties of curcumin-cellular and molecular mechanisms of action: B. Joe, et al.; Crit. Rev. Food Sci. Nutr. 44, 97 (2004), (Review), Abstract;

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects: M.E. Egan, et al.; Science 304, 600 (2004), Abstract;

Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide: B.D. Johnston & E.G. DeMaster; Nitric Oxide 8, 231 (2003), Abstract;

Effect of curcumin on the production of nitric oxide by cultured rat mammary gland: M. Onoda & H. Inano; Nitric Oxide 4, 505 (2000), Abstract;

In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties: M.M. Chan, et al.; Biochem. Pharmacol. 55, 1955 (1998), Abstract;

Inhibitory effects of curcumin on tumorigenesis in mice: M.T. Huang, et al.; J. Cell. Biochem. (Suppl.) 27, 26 (1997), Abstract;

Nitric oxide scavenging by curcuminoids: Sreejayan & M.N. Rao; J. Pharm. Pharmacol. 49, 105 (1997), Abstract;

Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines: M.C. Jiang, et al.; Nutr. Cancer 26, 111 (1996), Abstract;

Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell: A.K. Singh, et al.; Cancer Lett. 107, 109 (1996), Abstract;

Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells: M.L. Kuo, et al.; Biochim. Biophys. Acta 1317, 95 (1996), Abstract;

Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin: J.N. Commandeur & N.P. Vermeulen; Xenobiotica 26, 667 (1996), Abstract;

Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages: I. Brouet & H. Okshima; BBRC 206, 533 (1995), Abstract;

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells: L. Korutla & R. Kumar; Biochim. Biophys. Acta 1224, 597 (1994), Abstract;

Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones: D.L. Flynn, et al.; Prostagl. Leukotr. Med. 22, 357 (1986), Abstract;

Modification of certain inflammation-induced biochemical changes by curcumin: R. Srivastava & R.C. Srimal; Indian J. Med. Res. 81, 215 (1985), Abstract;