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Curcumin (high purity)

Inhibitor of Lipoxygenase and COX
 
ALX-350-028-M010 10 mg 34.00 USD
 
ALX-350-028-M050 50 mg 84.00 USD
 
ALX-350-028-M250 250 mg 299.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-EI135

Dual inhibitor of 5-lipoxygenase (IC50=8µM) and cyclooxygenase (COX) (IC50=52µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells. Has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10µM), the COP9 signalosome kinase (IC50=10µM) and p300/CBP.

Product Specification

Alternative Name:1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane
 
Formula:C21H20O6
 
MW:368.4
 
Source:Isolated from turmeric (Curcuma longa).
 
CAS:458-37-7
 
MI:14: 2673
 
Purity:≥98% (HPLC)
 
Appearance:Orange-yellow crystalline powder.
 
Solubility:Soluble in acetic acid, 100% ethanol (at about 1mg/ml) or DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
ALX-350-028
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ALX-350-028

Product Literature References

Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes: A. Daverey, et al.; Neuroscience 333, 92 (2016), Application(s): Culture treatment, Abstract;
Curcumin Inhibits 3T3-L1 Preadipocyte Proliferation by Mechanisms Involving Post-transcriptional p27 Regulation: B.S. Ferguson, et al.; Biochem. Biophys. Rep. (2015), Application(s): Cell culture,
Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-Terminal Kinase (JNK)-Dependent Manner: T. S. Tirodkar, et al.; J. Biol. Chem. 290, 13157 (2015), Application(s): Cell Culture, Abstract; Full Text
Curcumin Extract for Prevention of Type 2 Diabetes: S. Chuengsamarn, et al.; Diabetes Care 35, 2121 (2012), Abstract;
Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression: S.A. Shah, et al.; Cancer Res. 72, 1248 (2012), Abstract;
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats: T. Morimoto, et al.; J. Clin. Invest. 118, 868 (2008), Abstract; Full Text
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species: M. Panchatcharam, et al.; Mol. Cell Biochem. 290, 87 (2006), Abstract;
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1: M.K. Bae, et al.; Oncol. Rep. 15, 1557 (2006), Abstract;
Curcumin is an inhibitor of p300 histone acetylatransferase: M.G. Marcu, et al.; Med. Chem. 2, 169 (2006), Abstract;
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases: S. Bengmark; JPEN J. Parenter. Enteral. Nutr. 30, 45 (2006), (Review), Abstract;
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia: K.K. Jung, et al.; Life Sci. 79, 2022 (2006), Abstract;
Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006), (Review), Abstract;
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells: Z. Wang, et al.; Cancer 106, 2503 (2006), Abstract;
Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin: B.S. Park, et al.; J. Agric. Food Chem. 53, 9005 (2005), Abstract;
Immunomodulatory effects of curcumin: V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol. 27, 485 (2005), Abstract;
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin: P. Tsvetkov, et al.; PNAS 102, 5535 (2005), Abstract;
Biological properties of curcumin-cellular and molecular mechanisms of action: B. Joe, et al.; Crit. Rev. Food Sci. Nutr. 44, 97 (2004), (Review), Abstract;
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects: M.E. Egan, et al.; Science 304, 600 (2004), Abstract;
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide: B.D. Johnston & E.G. DeMaster; Nitric Oxide 8, 231 (2003), Abstract;
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland: M. Onoda & H. Inano; Nitric Oxide 4, 505 (2000), Abstract;
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties: M.M. Chan, et al.; Biochem. Pharmacol. 55, 1955 (1998), Abstract;
Inhibitory effects of curcumin on tumorigenesis in mice: M.T. Huang, et al.; J. Cell. Biochem. (Suppl.) 27, 26 (1997), Abstract;
Nitric oxide scavenging by curcuminoids: Sreejayan & M.N. Rao; J. Pharm. Pharmacol. 49, 105 (1997), Abstract;
Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines: M.C. Jiang, et al.; Nutr. Cancer 26, 111 (1996), Abstract;
Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell: A.K. Singh, et al.; Cancer Lett. 107, 109 (1996), Abstract;
Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells: M.L. Kuo, et al.; Biochim. Biophys. Acta 1317, 95 (1996), Abstract;
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin: J.N. Commandeur & N.P. Vermeulen; Xenobiotica 26, 667 (1996), Abstract;
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages: I. Brouet & H. Okshima; BBRC 206, 533 (1995), Abstract;
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells: L. Korutla & R. Kumar; Biochim. Biophys. Acta 1224, 597 (1994), Abstract;
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones: D.L. Flynn, et al.; Prostaglandins Leukot. Med. 22, 357 (1986), Abstract;
Modification of certain inflammation-induced biochemical changes by curcumin: R. Srivastava & R.C. Srimal; Indian J. Med. Res. 81, 215 (1985), Abstract;

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