Daidzein

Genistein analog



ALX-350-009-M010	10 mg	13.00 USD

ALX-350-009-M025	25 mg	26.00 USD

ALX-350-009-M050	50 mg	39.00 USD

Replaces Prod. #: BML-ST110

Inactive analog of the tyrosine kinase inhibitor genistein (Prod. No. ALX-350-006). Shares with genistein a number of effects thought to be unrelated to tyrosine kinase inhibition. These include activation of the human estrogen receptor, induction of differentiation in leukemia cells and inhibition of fast Na⁺ channels. Shows anti-inflammatory effect.

Product Specification

Alternative Name:	4',7-Dihydroxyisoflavone

Formula:	C₁₅H₁₀O₄

MW:	254.2

Purity:	≥98%

Appearance:	White to off-white solid.

CAS:	486-66-8

MI:	14: 2801

RTECS:	DJ3100040

Source/Host:	Synthetic.

Solubility:	Soluble in DMSO (25mg/ml); slightly soluble in 100% ethanol (2mg/ml); insoluble in water.

Long Term Storage:	-20°C

Hazard:	IRRITANT.

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Product Literature References

Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review, Abstract;

Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006), Abstract;

Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005), Abstract;

Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health: C. Atkinson, et al.; Exp. Biol. Med. (Maywood) 230, 155 (2005), Review, Abstract;

Genistein inhibition of fast Na+ current in uterine leiomyosarcoma cells is independent of tyrosine kinase inhibition: M. Kusaka & N. Sperelakis; Biochim. Biophys. Acta 1278, 1 (1996), Abstract;

Structural requirements for differentiation-induction and growth-inhibition of mouse erythroleukemia cells by isoflavones: Y. Jing & S. Waxman; Anticancer Res. 15, 1147 (1995), Abstract;

Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells: K. Higashi and H. Ogawara; Biochim. Biophys. Acta 1221, 29 (1994), Abstract;

Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994), Abstract;

Stimulation of pS2 expression by diet-derived compounds: N. Sathyamoorthy, et al.; Cancer Res. 54, 957 (1994), Abstract;

Genistein and daidzein, and their ß-glycoside conjugates: anti-tumor isoflavones in soybean foods from American and Asian diets: L. Coward, et al.; J. Agric. Food Chem. 41, 1961 (1993),

Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils: S.E. Lavens, et al.; Am. J. Respir. Cell. Mol. Biol. 7, 637 (1992), Abstract;

Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells: S. Wijetunge, et al.; BBRC 189, 1620 (1992), Abstract;

Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987), Abstract; Full Text