Genistein (synthetic)

Tyrosine kinase inhibitor



ALX-350-006-M010	10 mg	30.00 USD

ALX-350-006-M025	25 mg	55.00 USD

ALX-350-006-M050	50 mg	98.00 USD

ALX-350-006-M100	100 mg	163.00 USD

ALX-350-006-G001	1 g	520.00 USD

Replaces Prod. #: BML-EI147

Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Potent inhibitor of α-glucosidase, IC₅₀ = 50nM.Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC₅₀=20µM).

Product Specification

Alternative Name:	4',5,7-Trihydroxyisoflavone

Formula:	C₁₅H₁₀O₅

MW:	270.2

Purity:	≥99% (HPLC)

Appearance:	White to yellow crystalline powder.

CAS:	446-72-0

MI:	14: 4391

RTECS:	NR2392000

Source/Host:	Synthetic.

Solubility:	Soluble in DMSO (30mg/ml), 100% ethanol (4mg/ml) or dilute aqueous base; insoluble in water.

Long Term Storage:	+4°C

Hazard:	HARMFUL. MAY BE CARCINOGENIC.

Handling:	Protect from light.

Background / Technical Information:	Replacement for ADI-HPK-103

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Product Literature References

Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review, Abstract;

Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006), Abstract;

The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy: F.H. Sarkar, et al.; Mini Rev. Med. Chem. 6, 401 (2006), Review, Abstract;

Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005), Abstract;

Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 325, 511 (2005), Abstract;

Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol. 4, 185 (2004), Abstract;

Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy: N. Dijsselbloem, et al.; Biochem. Pharmacol. 68, 1171 (2004), Review, Abstract;

Mechanisms of cancer chemoprevention by soy isoflavone genistein: F.H. Sarkar & Y. Li; Cancer Metastasis Rev. 21, 265 (2002), Abstract;

Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor: D.S. Lee & S.H. Lee; FEBS Lett. 501, 84 (2001), Abstract;

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release: P.J. Lane et al.; J. Immunol. 146, 715 (1991), Abstract;

Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase: J.M. Trevillyan et al.; J. Immunol. 145, 3223 (1990), Abstract;

Effect of genistein, a tyrosine kinase inhibitor, on U46619-induced phosphoinositide phosphorylation in human platelets: D.C. Gaudette & J. B. Holub; Biochem. Biophys. Res. Commun. 170, 238 (1990), Abstract;

Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett. 263, 104 (1990), Abstract;

Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity: C. Linassier et al.; Biochem. Pharmacol. 39, 187 (1990), Abstract;

Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with genistein and monoclonal antibody to phosphotyrosine: A. Dhar et al.; Mol. Pharmacol. 37, 519 (1990), Abstract;

T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation: T. Mustelin et al.; Science 247, 1584 (1990), Abstract;

J. Markovits et al.; Cancer Res. 49, 5711 (1989),

Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells: N.M. Dean et al.; Biochem. Biophys. Res. Commun. 165, 795 (1989), Abstract;

Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987), Abstract; Full Text