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Methyl Phytoprostane B1 (Type I) (racemic)

GST activator
ALX-340-062-M005 5 mg 281.00 USD
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Prostaglandin/jasmonate-like product of nonenzymatic lipid peroxidation. Occurs ubiquitously in healty plants and increases in response to oxidative stress. Could potentially be used as a marker of oxidative degradation of plant derived food. Powerful inducer of glutathione-S-transferase, jasmonic acid and other stress related responses. The role of phytoprostanes in human nutrition is not clarified yet, but they are associated with inhibition of dendritic cell interleukin-12 production and augmentation of TH2 cell polarization.

Product Specification

Alternative Name:Methyl-8-(2-((E)-3-hydroxypent-1-enyl)-5-oxocyclopent-1-enyl)octanoate (racemic)
Purity:≥95% (13C-NMR)
Identity:Determined by 1H-NMR, 13C-NMR and MS.
Appearance:Colourless liquid.
Solubility:Soluble in 100% ethanol, methanol, ether, ethyl acetate or halogenic solvents.
Long Term Storage:+4°C
Handling:Protect from light and moisture.
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Product Literature References

A flexible synthesis of the phytoprostanes B1 type I and II: S. El Fangour, et al.; J. Org. Chem. 70, 989 (2005), Abstract;
B1-phytoprostanes trigger plant defense and detoxification responses: C. Loeffler, et al.; Plant Physiol. 137, 328 (2005), Abstract;
Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization: C. Traidl-Hoffmann, et al.; J. Exp. Med. 201, 627 (2005), Abstract; Full Text
The isoprostanoid pathway in plants: I. Thoma, et al.; Chem. Phys. Lipids 128, 135 (2004), Abstract;

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