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D-myo-Inositol 1,4,5-trisphosphate (caged) . trisodium salt

 
ALX-307-070-C010 10 µg 179.00 USD
 
ALX-307-070-C100 100 µg 637.00 USD
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Ins (1,4,5)P3 derivative with a cage on position 4, which does not show biological activity until photochemical destruction of the cage. A short light pulse (254 or 360nm) releases active Ins(1,4,5)P3 within a second, thus mimicking the rapid responses of the receptor/phospholipase C signalling system in the cell. Since this approach does not (directly) trigger other signalling events, for instance protein kinase C (PKC) activation after receptor-mediated diacylglycerol (DAG) formation, these molecules are exciting tools to help dissect signalling pathways. This photolabile derivative of Ins(1,4,5)P3 is not metabolized by endogenous phosphatase (extinction coefficient: 4240M-1cm-1; 265nm, water).

Product Specification

Alternative Name:Ins(1,4,5)P3 (caged) . 3Na, D-myo-Inositol 1,4,5-trisphosphate, P4-1-(2-nitrophenyl)ethyl ester . 3Na
 
Formula:C14H19NO17P3 . 3Na
 
MW:566.2 . 69.0
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
307-070
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307-070

Product Literature References

Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate: J.W. Walker, et al.; Nature 327, 249 (1987), Abstract;

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