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α-GalCer Analog 8

TCR activator
 
ALX-306-033-C500 500 µg 259.00 USD
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Natural killer T cell (NKT) T cell receptor (TCR) agonist. Derivative of α-GalCer (the first defined and most potent agonistic antigen of TCR known so far). Stimulates the production of smaller amounts of IFN-γ than α-GalCer, but  induces equal or greater IL-4 secretion in mouse models.

Product Specification

Alternative Name:α-Galactosylceramide Analog 8
 
Formula:C50H97N3O8
 
MW:868.3
 
Source:Synthetic
 
Purity:≥95% (1H-NMR)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol, chloroform, DMSO, dimethyl formamide (warm), methanol or pyridine.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Scientific Background:Natural killer T (NKT) cells are a unique subset of T cells. Unlike other T cells, NKT recognize glycolipid antigens presented by the major histocompatibility complex (MHC) class I-like molecule CD1d. Upon recognition of the CD1d/glycolipid complex through TCR, NKT cells rapidly produce Th1 and Th2 cytokines such as IFN-γ and IL-4. The most well-studied example is the CD1d-presented TCR antigen α-galactosylceramide (α-GalCer). α-GalCer, originally isolated from the marine sponge Agelas mauritianus, has been shown to be a highly potent, immunomodulatory compound. Meanwhile, various structural analogs of α-GalCer have been produced and their immunomodulating activities are being tested to assess the potential as drugs for the treatment of various autoimmune diseases and cancer.
 
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Product Literature References

CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice: G.H.M. van Pujivelde et al.; PLoS One 13, e0190962 (2018), Abstract; Full Text
Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer: T. Lee, et al.; J. Med. Chem. 50, 585 (2007), Abstract;

General Literature References

Glycolipids as immunostimulating agents.: D. Wu, et al; Bioorg. Med. Chem. 16, 1073 (2007), Review, Abstract; Full Text

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