α-GalCer Analog 8

TCR activator



ALX-306-033-C500	500 µg	206.00 USD

Natural killer T cell (NKT) T cell receptor (TCR) agonist. Derivative of α-GalCer (the first defined and most potent agonistic antigen of TCR known so far). Stimulates the production of smaller amounts of IFN-γ than α-GalCer, but induces equal or greater IL-4 secretion in mouse models.

Product Specification

Alternative Name:	α-Galactosylceramide Analog 8

Formula:	C₅₀H₉₇N₃O₈

MW:	868.32

Purity:	≥95% (¹H-NMR)

Appearance:	White solid.

Source/Host:	Synthetic

Solubility:	Soluble in 100% ethanol, chloroform, DMSO, dimethyl formamide (warm), methanol or pyridine.

Long Term Storage:	-20°C

Background / Technical Information:	Natural killer T (NKT) cells are a unique subset of T cells. Unlike other T cells, NKT recognize glycolipid antigens presented by the major histocompatibility complex (MHC) class I-like molecule CD1d. Upon recognition of the CD1d/glycolipid complex through TCR, NKT cells rapidly produce Th1 and Th2 cytokines such as IFN-γ and IL-4. The most well-studied example is the CD1d-presented TCR antigen α-galactosylceramide (α-GalCer). α-GalCer, originally isolated from the marine sponge Agelas mauritianus, has been shown to be a highly potent, immunomodulatory compound.Meanwhile, various structural analogs of α-GalCer have been produced and their immunomodulating activities are being tested to assess the potential as drugs for the treatment of various autoimmune diseases and cancer.

Please mouse over

Product Literature References

Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer.: T. Lee, et al.; J. Med. Chem. 50, 585 (2007), Abstract;