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OCH

 
ALX-306-029-C250 250 µg 132.00 USD
 
ALX-306-029-M001 1 mg 269.00 USD
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Truncated analog of α-Gal-Cer. Selectively induces IL-4, as opposed to IFN-γ. Offers protection in mouse against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Also offers protection against diabetes in NOD mice and against collagen induced arthritis. Stimulation of NKT cells with α-Gal-Cer results in release of a mixture of Th1 and Th2 cytokines, stimulation with OCH results in release of primarily Th2 cytokine.

Product Specification

Alternative Name:(2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-2-tetracosanoyl-aminononan-3,4-diol
 
Formula:C39H78NO9
 
MW:704.1
 
Purity:≥95% (1H-NMR and TLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO, 100% ethanol (warm) or methanol (warm).
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:After reconstitution, aliquot into glass vials.
 
306-029
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306-029

Product Literature References

Innate Immunity Drives the Initiation of a Murine Model of Primary Biliary Cirrhosis: C. H. Chang, et al.; PLoS One 10, e0121320 (2015), Application(s): Injection in mouse, Abstract; Full Text
Glycolipids for natural killer T cells: P.B. Savage, et al.; Chem. Soc. Rev. 351, 771 (2006), Abstract;
Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH: R.M. Ndonye, et al.; J. Org. Chem. 70, 10260 (2005), Abstract;
Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (alpha-d-galactosyl)-2- tetracosanoylamino-1,3,4-nonanetriol: K. Murata, et al.; J. Org. Chem. 70, 2398 (2005), Abstract;

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