A photolyzable derivative of sphingosine 1-phosphate (1-SPP) (Prod. No. BML-SL140). Important tool for the study of 1-SPP mediated intracellular events.
Product Details
| Alternative Name: | 1-SPP (caged) |
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| Formula: | C34H52N3O9P |
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| MW: | 677.8 |
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| Source: | Synthetic. |
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| Purity: | ≥95% |
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| Appearance: | Clear to slight yellow oil. |
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| Solubility: | Soluble in methanol or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1: K. Zmajkovicova, et al.; PLoS One
15, e0228195 (2020),
Abstract;
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Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells: L.H. Hadi, et al.; PLoS One
10, e0143384 (2015),
Application(s): Sphingolipid release in Cell Culture,
Abstract;
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S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells: K.P. Hopson, et al.; Am. J. Physiol. Cell Physiol.
300, C919 (2011),
Abstract;
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An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival: T. Blom, et al.; BMC Cell Biol.
11, 45 (2010),
Abstract;
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Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries: S. Salomone, et al.; Pharmacol. Res.
62, 465 (2010),
Abstract;
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Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.: D. Meyer zu Heringdorf, et al.; FEBS Lett.
554, 443 (2003),
Abstract;
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.: F. Wang, et al.; Cancer Res.
59, 6185 (1999),
Abstract;
Synthesis and evaluation of a photolyzable derivative of sphingosine 1- phosphate--caged SPP: L. Qiao, et al.; Bioorg. Med. Chem. Lett.
8, 711 (1998),
Abstract;
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