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MSDH-C

Glycosphingolipid biosynthesis inhibitor
 
ALX-303-005-M001 1 mg 133.00 USD
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Potent inhibitor of the glycosphingolipid biosynthesis. At 10µM decreases de novo ceramide biosynthesis by about 90%.

Product Specification

Alternative Name:D-erythro-1-Methylthiohydroceramide, (2R,3R)-(2-N-Lauroyl)-amino-1-methylthio-3-hydroxy-nonan
 
Formula:C22H45NO2S
 
MW:387.7
 
CAS:144474-37-3
 
Purity:≥95%
 
Identity:Identity determined by MS, 1H- and 13C-NMR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or methanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
303-005
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303-005

Product Literature References

1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis: G. van Echten-Deckert, et al.; J. Biol. Chem. 273, 1184 (1998), Abstract; Full Text
Synthesis of potential inhibitors of the glycosphingolipid biosynthesis: G. Brenner-Weiss, et al.; Tetrahedron 48, 5855 (1992),

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