Induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis.
Product Details
Alternative Name: | Disialoganglioside GD3 . 2Na (bovine buttermilk), GD3 . 2Na (bovine buttermilk) |
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Sequence: | [Il3(Neu5Ac)2LacCer] [[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer] |
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Formula: | C70H123N3O29 . 2Na |
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MW: | 1470.8 . 46.0 (calculated on sphingosine C18:1 and stearic acid) |
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Source: | Bovine buttermilk |
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CAS: | 62010-37-1 |
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Purity: | ≥98% (TLC) |
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Appearance: | Lyophilized. |
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Solubility: | Soluble in chloroform/methanol, 2:1 |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells: S. Watanabe, et al.; Neurosci. Lett.
517, 140 (2012),
Abstract;
Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria: Y. Inoki, et al.; BBRC
276, 1210 (2000),
Abstract;
Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition: B.S. Kristal & A.M. Brown; J. Biol. Chem.
274, 23169 (1999),
Abstract;
Full Text
Ganglioside GD3, the mitochondrial permeability transition, and apoptosis: B.S. Kristal & A.M. Brown; Ann. NY Acad. Sci.
893, 321 (1999), (Review),
Abstract;
Lipid signaling in CD95-mediated apoptosis: F. Malisan & R. Testi; FEBS Lett
452, 100 (1999), (Review),
Abstract;