Replaces Prod. #: ALX-302-008
Differentiation marker for cell growth. Protein kinase C (PKC) inhibitor. The major ganglioside of the nervous system.
Product Details
| Alternative Name: | Disialoganglioside GD1a . 2Na (bovine brain), GD1a . 2Na (bovine brain) |
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| Sequence: | [II3(Neu5Ac),IV3(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal-(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer] |
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| Formula: | C84H146N4O39 . 2Na |
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| MW: | 1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid) |
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| CAS: | 12707-58-3 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Lyophilized. |
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| Solubility: | Soluble in chloroform/methanol/DI water, 2:1:0.1 |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Anti-inflammatory role of GM1 and other gangliosides on microglia: D. Galleguillos, et al.; J. Neuroinflammation
19, 9 (2022),
Abstract;
Full Text
Bifunctional hetero di-disc for broad-spectrum influenza neutralization: S. Moon, et al.; Nanomedicine
44, 102587 (2022),
Abstract;
Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-κB signaling pathways through TLR4: Y. Wang, et al.; Int. Immunopharmacol.
28, 136 (2015),
Application(s): Cell Culture,
Abstract;
Chromatographic Separation of Human Brain Gangliosides: L. Svennerholm; J. Neurochem.
10, 613 (1963),
Abstract;
