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BIX 01294 . trihydrochloride

G9a histone methyltransferase inhibitor
 
ALX-270-517-M005 5 mg 103.00 USD
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Selective and cell permeable inhibitor of G9a histone methyltransferase. Modulates H3K9me2 levels in mammalian cells. Potentiates induction of pluripotent stem cells from somatic cells in vitro. Enables neural progenitor cells to be reprogrammed in the absence of exogenous Oct4.

Product Specification

Formula:C28H38N6O2 . 3HCl
 
MW:490.6 . 109.4
 
CAS:935693-62-2
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (5mg/ml) or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light. Keep under inert gas.
 
ALX-270-517 structure
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ALX-270-517 structure

Product Literature References

Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach: J.R. Plews, et al.; PLoS One 5, e14397 (2010), Abstract;
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds: Y. Shi, et al.; Cell Stem Cell 3, 568 (2008), Abstract;
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase: S. Kubicek, et al.; Mol. Cell 25, 473 (2007), Abstract;

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BIX 01294 . trihydrochloride . hydrate 

G9a histone methyltransferase inhibitor
935693-62-2, ≥95% (HPLC) | Print as PDF
 
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