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MS-1020

JAK3 inhibitor
 
ALX-270-513-M001 1 mg 78.00 USD
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Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression.

Product Specification

Formula:C21H18N2O3
 
MW:346.4
 
Source:Synthetic derivative of Nb-(p-feruloyl)serotonin from Phragmites communis extract.
 
Purity:≥95% (NMR)
 
Identity:Identity determined by 1H- & 13C-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (at least 5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Protect from light.
 
270-513
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270-513

Product Literature References

MS-1020 is a novel small molecule that selectively inhibits JAK3 activity: B.H. Kim, et al.; Br. J. Haematol. 148, 132 (2010), Abstract; Full Text
Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway: C.J. Malemud; Pharmaceuticals 3, 1446 (2010), Full Text

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