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United States 

WK-X-34

Inhibitor of P-glycoprotein and BCRP
 
ALX-270-510-M001 1 mg 206.00 USD
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A potent inhibitor of P-glycoprotein (ABCB1) and breast cancer resistant protein (BCRP; ABCG2).

Product Specification

Alternative Name:N-(2-{4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isochinolin-2-yl)-ethyl]phenylcarbamoyl}phenyl)-3,4-dimethoxybenzamide
 
Formula:C35H37N3O6
 
MW:595.7
 
CAS:908859-10-9
 
Purity Detail:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 2 months at -20°C.
 
270-510
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270-510

Product Literature References

Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors: H. Muller, et al.; Bioorg. Med. Chem. 16, 2448 (2008), Abstract;
Novel tetrahydroisoquinolin-ethyl-phenylamine based multidrug resistance inhibitors with broad-spectrum modulating properties: V. Jekerle, et al.; Cancer Chemother. Pharmacol. 59, 61 (2007), Abstract;
99mTc-Sestamibi, a sensitive probe for in vivo imaging of P-glycoprotein inhibition by modulators and mdr1 antisense oligodeoxynucleotides: V. Jekerle, et al.; Mol. Imaging Biol. 8, 333 (2006), Abstract;
In vitro and in vivo evaluation of WK-X-34, a novel inhibitor of P-glycoprotein and BCRP, using radio imaging techniques: V. Jekerle, et al.; Int. J. Cancer 119, 414 (2006), Abstract;

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