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(S)-CR8

Inhibitor of CDK and GSK
 
ALX-270-509-M005 5 mg 217.00 USD
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Potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, 7 and 9. Two to four-fold more potent inhibitor of CDKs than (R)-roscovitine (Prod. No. BML-CC205). Induces apoptotic cell death more potently than (R)-roscovitine. Equally potent inhibitor of CDKs as (R)-CR8. Less potent glycogen synthase kinase (GSK-3α/β) inhibitor than (R)-CR8.

Product Specification

Formula:C24H29N7O
 
MW:431.5
 
Source:Synthetic.
 
CAS:1084893-56-0
 
Purity:≥97% (NMR)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas.
 
Scientific Background:The 20 cyclin-dependent kinases (CDKs) belong to an extensively studied and well-conserved family of kinases. Experiments have shown that thirteen of the 20 CDKs are activated by the binding of the regulatory partner cyclin. In conjunction with cyclins and through complex pathways, CDKs regulate diverse key transitions of the cell division cycle. A plethora of abnormalities in the regulation and activity of CDKs have been described in various tumors.
 
270-509
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270-509

Product Literature References

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008), Abstract;

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CDK inhibitor
186692-46-6, ≥95% (HPLC, TLC) | Print as PDF
 
BML-CC205-0002 2 mg 74.00 USD
 
BML-CC205-0005 5 mg 167.00 USD
Do you need bulk/larger quantities?
 

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