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trans-Ned-19

 
ALX-270-503-MC05 0.5 mg 211.00 USD
 
ALX-270-503-M001 1 mg 326.00 USD
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Cell permeable, selective and potent inhibitor of nicotinic acid adenine dinucleotide phosphate (NAADP) receptor in mammalian cells and sea urchin eggs. Blocks NAADP signaling. Inhibits Ca2+ release: trans-Ned-19 (IC50 = 6nM); cis-Ned-19 (IC50 = 800nM). [32P] NAADP binding: trans-Ned-19 (IC50 = 0.4nM); cis-Ned-19 (IC50 = 15µM). Inhibits Ca2+ release from lysosomes. Noncompetitive antagonist. Fluorescent.

Product Specification

Alternative Name:1-(3-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
 
Formula:C30H31FN4O3
 
MW:514.6
 
Source:Synthetic
 
Purity:≥97% (HPLC)
 
Identity:Determined by 1H-NMR, 13C-NMR and MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Scientific Background:NAADP (nicotinic acid adenine dinucleotide phosphate) is an emerging Ca2+ releasing second messenger in several mammalian tissues including pancreatic, brain and cardiac tissue.
 
Technical Info/Product Notes:Fluorescence of Ned-19 is compatible with visualization of the NAADP receptor in intact cells via confocal microscopy using an ultraviolet Argon ion laser (excitation 351 and 365 nm).
 
ALX-270-503 structure
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ALX-270-503 structure

Product Literature References

CD38-mediated Ca(2+) signaling contributes to glucagon-induced hepatic gluconeogenesis: S.Y. Rah, et al.; Sci. Rep. 5, 10741 (2015), Application(s): Cell Culture, Abstract; Full Text
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP: P. Gomez-Suaga, et al.; Hum. Mol. Genet. 21, 511 (2012), Abstract; Full Text
NAADP regulates human platelet function: C.H. Coxon, et al.; Biochem. J. 441, 435 (2012), Abstract; Full Text
Actions of the NAADP Antagonist Trans-Ned19 in Cardiac Ventricular Myocytes: L. Elson, et al.; Biophys. J. 100, 81a (2011),
NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells: B. Esposito, et al.; Blood 117, 4968 (2011), Abstract;
NAADP mediates ATP-induced Ca(2+) signals in astrocytes: M. Barcelo-Torns, et al.; FEBS Lett. 585, 2300 (2011), Abstract;
Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes: G.J. Pereira, et al.; J. Biol. Chem. 286, 27875 (2011), Abstract; Full Text
Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells: F. Zhang, et al.; Am. J. Physiol. Cell Physiol. 301, C421 (2011), Abstract;
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels: S. Patel, et al.; Cell Calcium 50, 157 (2011), Abstract;
A functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat: P.K. Aley, et al.; J. Pharmacol. Exp. Ther. 333, 726 (2010), Abstract;
Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure: G.C. Brailoiu, et al.; J. Biol. Chem. 285, 37133 (2010), Abstract;
Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways: E.U. Alejandro, et al.; Endocrinol. 151, 502 (2010), Abstract;
Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation: G.D. Dickinson, et al.; J. Biol. Chem. 285, 13321 (2010), Abstract;
Expecting to eat: glucagon-like peptide-1 and the anticipation of meals: D.L. Williams, et al.; Endocrinology 151, 445 (2010), Abstract; Full Text
Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels: P.K. Aley, et al.; PNAS 107, 19927 (2010), Abstract;
Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca(2+) Signaling and Endolysosomal Trafficking: M. Ruas, et al.; Curr. Biol. 20, 703 (2010), Abstract;
TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+: S.J. Pitt, et al.; J. Biol. Chem. 285, 35039 (2010), Abstract;
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor: D. Rosen, et al.; J. Biol. Chem. 284, 34930 (2009), Abstract;
Identification of a chemical probe for NAADP by virtual screening: E. Naylor, et al.; Nat. Chem. Biol. 4, 220 (2009), Abstract;
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles: T.L. Thai, et al.; Am. J. Physiol. Renal Physiol. 297, F510 (2009), Abstract;
NAADP: a universal Ca2+ trigger: A.H. Guse & H.C. Lee; Sci. Signal. 1, re10 (2008), Abstract;

General Literature References

The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction: S.R. Vasudevan, et al.; J. Biol. Chem. 285, 18262 (2010), Abstract;

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