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Dynasore

GTPase inhibitor
 
ALX-270-502-M005 5 mg 53.00 USD
 
ALX-270-502-M025 25 mg 168.00 USD
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Small molecule GTPase inhibitor targeting Dynamin-1, Dynamin-2 and Drp1 (mitochondrial Dynamin). Noncompetitive inhibitor of Dynamin GTPase activity. Blocks Dynamin-dependent endocytosis in cells (including neurons). Fast acting (seconds). Strong, dose dependent block of the traffic and accumulation of transferrin with 80µM dynasore (IC50 = 15µM). Has also been shown to block human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.

Product Specification

Formula:C18H14N2O4
 
MW:322.3
 
CAS:304448-55-3
 
Purity:≥98% (HPLC, TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in 100% ethanol (1mg/ml) or DMSO (10mg/ml); insoluble in water.
 
Shipping:Ambient
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from light. Keep under inert gas.
 
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Product Literature References

c-jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells: H. Choi, et al.; Free Radic. Biol. Med. 86, 219 (2015), Abstract;
PKCε-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2: C.T. Hu, et al.; Cell. Signal. 27, 1544 (2015), Application(s): Cell Culture, Abstract;
Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages: E.S. Barrias, et al.; PLoS One 5, e7764 (2010), Abstract; Full Text
Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis: M. Husmann, et al. ; FEBS Lett. 583, 337 (2009), Abstract;
Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis: T. Kirchhausen, et al.; Meth. Enzymol. 438, 77 (2008), Abstract;
A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating: R.H. Massol, et al.; PNAS 103, 10265 (2006), Abstract; Full Text
Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation: S.R. Nankoe, et al.; Trends Cell Biol. 16, 607 (2006), Abstract;
Dynasore, a cell-permeable inhibitor of dynamin: E. Macia, et al. ; Dev. Cell 10, 839 (2006), Abstract;
Identification of alkylidene hydrazides as glucagon receptor antagonists: A. Ling, et al.; J. Med. Chem. 44, 3141 (2001), Abstract;

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