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Finasteride

5α-reductase inhibitor
 
ALX-270-491-M100 100 mg 78.00 USD
 
ALX-270-491-M500 500 mg 312.00 USD
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Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Used as a treatment in benign prostatic hyperplasia and prostate cancer. Also used to treat male pattern hair loss.

Product Specification

Alternative Name:MK-906
 
Formula:C23H36N2O2
 
MW:372.5
 
CAS:98319-26-7
 
MI:14: 4082
 
RTECS:CL5245000
 
Purity:≥98% (Assay (UV))
 
Identity:Determined by IR.
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble in DMSO, 100% ethanol, methanol or propanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-491
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270-491

Product Literature References

Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures: Y. Ishihara, et al.; Steroids 113, 71 (2016), Application(s): Examination of the protective mechanism of progesterone against OGD/reoxygenation-induced neurotoxicity, Abstract;
Anti-nociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals: D. Duborija-Kovacevic, et al.; Eur. J. Drug Metab. Pharmacokinet. 33, 181 (2008), Abstract;
Finasteride for prostatic disease: an updated and comprehensive review: C. De Nunzio, et al.; Expert Opin. Drug Metab. Toxicol. 4, 1561 (2008), (Review), Abstract;
Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line: J.M. Golbano, et al.; Int. J. Oncol. 32, 919 (2008), Abstract;
A new look at the 5alpha-reductase inhibitor finasteride: D.A. Finn, et al.; CNS Drug Rev. 12, 53 (2006), (Review), Abstract;
Finasteride in the treatment of alopecia: J.F. Libecco & W.F. Bergfeld; Expert Opin. Pharmacother. 5, 933 (2004), (Review), Abstract;
Finasteride: the first 5 alpha-reductase inhibitor: S.L. Sudduth & M.J. Koronkowski; Pharmacotherapy 13, 309 (1993), (Review), Abstract;
Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding: G.H. Rasmusson, et al.; J. Med. Chem. 29, 2298 (1986), Abstract;

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