Finasteride - Enzo Life Sciences

ALX-270-491

Revised 01-Feb-10

Finasteride
SYNONYMS	MK-906
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Androgens & Androgen Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-491-M100		100 mg	65.00 USD
ALX-270-491-M500		500 mg	260.00 USD

Product Specification

FORMULA:	C₂₃H₃₆N₂O₂
MW:	372.6
CAS NUMBER:	98319-26-7
MERCK INDEX:	14: 4082
RTECS:	CL5245000
PURITY:	≥98% (UV)
APPEARANCE:	White to off-white crystalline powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol, methanol or propanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	MAY BE TERATOGENIC. HARMFUL.
IDENTITY:	Identity determined by IR.

Product Description

Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Used as a treatment in benign prostatic hyperplasia and prostate cancer. Also used to treat male pattern hair loss.

Product Specific Literature References

Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding: G.H. Rasmusson, et al.; J. Med. Chem. 29, 2298 (1986) Abstract
Finasteride: the first 5 alpha-reductase inhibitor: S.L. Sudduth & M.J. Koronkowski; Pharmacotherapy 13, 309 (1993), (Review) Abstract
Finasteride in the treatment of alopecia: J.F. Libecco & W.F. Bergfeld; Expert Opin. Pharmacother. 5, 933 (2004), (Review) Abstract
A new look at the 5alpha-reductase inhibitor finasteride: D.A. Finn, et al.; CNS Drug Rev. 12, 53 (2006), (Review) Abstract
Finasteride for prostatic disease: an updated and comprehensive review: C. De Nunzio, et al.; Expert Opin. Drug Metab. Toxicol. 4, 1561 (2008), (Review) Abstract
Anti-nociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals: D. Duborija-Kovacevic, et al.; Eur. J. Drug Metab. Pharmacokinet. 33, 181 (2008) Abstract
Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line: J.M. Golbano, et al.; Int. J. Oncol. 32, 919 (2008) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Inhibitors)