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N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthylamide

Jnk inhibitor
 
ALX-270-490-M005 5 mg 324.00 USD
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Thienylnaphthamide compound. Potent inhibitor of JNK2 (pIC50=6.5) and JNK3 (pIC50=6.7) targeting the ATP-binding site. Has no activity against JNK1.

Product Specification

Formula:C20H16N2OS . H2O
 
MW:332.4 . 18.0
 
CAS:312917-14-9
 
Purity:≥95% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Tan solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
 
Handling:Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
 
270-490
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270-490

Product Literature References

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3: R.M. Angell, et al.; Bioorg. Med. Chem. Lett. 17, 1296 (2007), Abstract;

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