Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide

Jnk inhibitor
 
ALX-270-489-M005 5 mg 348.00 USD
Do you need bulk/larger quantities?
 
Pyridinylamide compound. Cell permeable, ATP-competitive, reversible inhibitor of JNK1 (Ki=2nM), JNK2 (Ki=4nM) and JNK3 (Ki=52nM). Inhibits c-Jun phosphorylation (EC50=920nM) in HepG2 cells. Blocks growth of PTEN null mouse embryonic fibroblasts.

Product Specification

Formula:C18H20N4O4
 
MW:356.4
 
CAS:894804-07-0
 
Purity:≥95% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Brown solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
 
270-489
Please mouse over
270-489

Product Literature References

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN: I. Vivanco, et al.; Cancer Cell 11, 555 (2007), Abstract;
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity: B.G. Szczepankiewicz, et al.; J. Med. Chem. 49, 3563 (2006), Abstract;

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,